receptor superfamily

Progress in nuclear receptor superfamily and nuclear receptor regulator

核受体超家族及其辅调节子的研究进展

Cytokine Receptor Superfamily and Its Role in Signal Transduction

细胞因子受体超家族与信号转导

Most of death receptors in this pathway belong to the tumour necrosis factor receptor superfamily .

死亡途径中大多数死亡受体属于肿瘤坏死因子受体超家族。

Members of TNF receptor superfamily including Fas are involved in the regulation of activation-induced cell death .

TNF受体超家族成员包括Fas是其中重要的介导分子。

The cytokine receptor superfamily and its role in mediating new pathways of signal transduction become more attractive than ever .

细胞因子受体超家族及其介导信号转导的新途径已引起人们的广泛注意。

GCNF ( Germ Cell Nuclear Factor ) is a member of nuclear receptor superfamily and also an orphan receptor .

GCNF（GermCellNuclearFactor）属于核受体超家族成员，是一个孤儿受体。

Background Liver X receptors ( LXRs ) are members of the nuclear hormone receptor superfamily which involve in energy metabolism of intracellular cholesterol and glucose regulation .

背景肝X受体是一种核受体，与细胞内胆固醇及糖等能量代谢有关。

RANK , a member of the tumor necrosis factor receptor superfamily , is involved in several signal transduction pathways and regulates the proliferation and differentiation of osteoclasts .

RANK是肿瘤坏死因子受体超家族成员，参与组成多条信号传导通路，调节破骨细胞等的增殖分化。

The nuclear receptor superfamily is composed of a large number of ligand-dependent transcriptional factors that mediate expression of genes associated with eukaryotic growth , development , and homeostasis .

核受体超家族属于反式作用因子，是一类配体依赖性转录因子，其成员广泛介导了真核生物与生长、发育和内环境稳定相关基因的表达。

Background and Objective : Peroxisome proliferator-activated receptors ( PPARs ) are a class of ligand-activated nuclear transcription factor belonging to the nuclear receptor superfamily .

研究背景和目的：过氧化物酶体增殖物激活受体（PPARs）是一类由配体激活的核转录因子，属于核内受体超家族成员。

Fas / FasL belong to the nerve growth factor / tumor necrosis factor receptor superfamily . Many kinds of tissues express Fas , but FasL is mainly expressed in activated lymphocytes .

Fas受体和它的天然配体FasL同属肿瘤坏死因子／神经生长因子（TNF/NGF）受体家族，Fas可表达于多种正常组织，而FasL主要表达于激活的免疫细胞。

Thyroid hormone receptors ( TRs ) belong to the nuclear hormone receptor superfamily . TRs are coded by two separate genes , TR α and TR β .

甲状腺激素受体（TRs）属于核受体超家族，由TRα和TRβ基因编码。

PPAR ( Peroxisome proliferator-activated receptors ), are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily that functions as critical regulators of lipid and energy homeostasis .

PPAR（peroxisomeproliferator-activatedreceptor），即过氧化物酶体增殖剂激活受体，是一类由配体激活的核转录因子，为核受体家族的一员。PPAR在调节脂类代谢及机体能量代谢平衡方面有重要作用。

As a member of the tumor necrosis factor ( TNF ) / nerve growth factor ( NGF ) receptor superfamily , Fas ( CD95 ) plays an important role in apoptosis and immunoregulation .

Fas/CD95作为肿瘤坏死因子（TNF）/神经生长因子（NGF）分子受体超家族成员，在细胞凋亡及体内免疫调节方面发挥重要的作用。

Sequences analysis showed that the predicted protein of the gene is basically characteristic of the low-density lipoprotein receptor superfamily ( LDLR ) when compare it with VgR / YPR and LDLR of other species .

将该基因片段的预测蛋白与其它物种的VgR/YPR和低密度脂蛋白受体（LDLR）家族比较，发现该基因具有LDLR家族的基本结构特征。

In the past , scientists persist that estrogen signals through ligand regulated transcription factors of the nuclear receptor superfamily . Estrogens binds to classical estrogen nuclear receptors ( ER ), then activate a serial of transduction signal proteins to elicit biological effects .

过去人们认为雌激素通过与经典的雌激素核受体结合，启动相关的基因效应，激活其下游一系列的信号转导蛋白而发挥相应的生物学作用。

The up-regulated genes mainly belonged to the tumor necrosis factor ( TNF ) ligand and receptor superfamily , Caspase family , Bcl-2 family , DNA damage checkpoint / P53 and ATM pathways , cell division cycle proteins and kinases , cyclin , cyclin - dependent kinases and inhibitors .

表达上调的基因主要包括肿瘤坏死因子配体和受体家族、半胱氨酸家族、Bcl-2家族、DNA损伤检测和P53途径和细胞分裂周期蛋白和激酶等；

A new member of the tumor necrosis factor receptor ( TNFR ) superfamily , Decoy receptor 3 ( DcR3 ), can reject the apoptosis as a special inhibitor of apoptosis .

诱骗受体3（DcR3）是肿瘤坏死因子受体（TNFR）超家族的新成员，是一种特殊的细胞凋亡抑制剂，具有抗凋亡特性。

Vitamin D receptor belongs to steroid-hormone receptor superfamily , and binds with calcitriol to regulate blood calcium and mineralization of bone .

维生素D受体是类固醇激素受体超家族的成员，与骨化三醇结合后能调节血钙和骨矿化。

Objective To explore the expression and distribution of germ cell nuclear factor ( GCNF ), an orphan receptor of the nuclear receptor superfamily which is supposed to have multifunction including spermatogenesis , neurogenesis and embryo development , in adult rat epididymis and young rats during postnatal development .

目的探讨生殖细胞核因子（GCNF）在大鼠附睾中的时空表达与分布。

CCK receptor belongs to G-protein-coupled receptor ( GPCR ) superfamily .

CCK受体属于G蛋白偶联受体。

The estrogen-related receptor ERR , belonging to the nuclear receptor superfamily , is the first orphan nuclear receptor to be identified . ERR comprise ERR α, ERR β and ERR γ .

雌激素相关受体（estrogen-relatedreceptor，ERR）属于核受体超家族，是第一个发现的孤儿核受体，包括ERRα，ERRβ和ERRγ。

Leptin receptor is a member of type I cytokine receptor superfamily and plays an important role in fatty acid metabolism .

Leptin受体OBR是Ⅰ类细胞因子家族成员，在Leptin的信号转导中起着极其重要的作用。

Receptor tyrosine kinase ( RTK ), a membrane receptor superfamily with intrinsic protein tyrosine kinase activity , has many members and complicated signal transduction pathways .

受体酪氨酸激酶是一个具有内在酪氨酸蛋白激酶活性的膜受体超家族，成员众多，信号转导通路复杂多样。

Estrogen receptor β( ER β), which belongs to the nuclear receptor superfamily and has high homology to ER α, is a ligand-regulated transcriptional factor . ER β is expressed in many tissues such as breast and so on , and has important physiological and pathological functions .

雌激素受体β（ERβ）与雌激素受体α（ERα）的结构相似，是一类配体调节的转录因子，属于核受体超家族，分布于乳腺等多种组织中，具有重要的生理病理学意义。

CD40 , a type I transmembrane glycoprotein with molecular weight of 48000 , belongs to nerve growth factor receptor ( NGFR ) and tumor necrosis factor receptor ( TNFR ) superfamily .

CD40为CD40L的受体，是相对分子质量（Mr）为48000的Ⅰ型跨膜糖蛋白，属于神经生长因子受体（NGFR）/肿瘤坏死因子受体（TNFR）超家族成员。

Estrogen receptor β( ER β) is a ligand-regulated transcriptional factor , which belongs to the nuclear receptor superfamily .

雌激素受体β（ERβ）属于核受体超家族成员，是一类配体调节的转录因子。

The very low density lipoprotein receptor ( VLDLR ) is a member of the low density lipoprotein receptor ( LDLR ) superfamily . It is composed of five section sharing structural homology with LDL .

极低密度脂蛋白受体（VLDLR）属于低密度脂蛋白受体（LDLR）超家族，结构上由五个结构域组成。

Growth hormone receptor ( GHR ) is a single membrane-spanning receptor , and belongs to the class I cytokine receptor superfamily . It binds to the growth hormone ( GH ) to initiate biological actions .

生长激素受体（GHR）是I型细胞因子受体超家族成员之一，它与配体生长激素（GH）结合发挥多种生理功能。

Fas receptor ( CD95 / Apo - 1 ) is one of the most important members in the TNF receptor superfamily . The interaction of Fas and its ligand ( FasL ) results in transduction of a cytolytic signal into the cell , regulating cell survival and death .

Fas（CD95／APO-1）是TNF受体超家族的重要成员，它通过与其配体FasL相互作用，激活一系列细胞内激酶，将死亡信号传导至细胞内，从而调控细胞的生存和凋亡。